Missile attacks in Syria, Lebanon, Iraq and Yemen threw into sharp focus the increasing risk of the war in Gaza triggering a wider regional conflict pitting Iran and its allies against Israel and the United States.

Iran said five of its Revolutionary Guards were killed in a missile strike on a house in Damascus which it blamed on Israel, and security sources in Lebanon said an Israeli strike there killed a member of Iran-backed Hezbollah.

Later on Saturday, missiles and rockets launched by Iran-backed militants in Iraq, where such groups have targeted US forces, hit al-Asad air base, the US Central Command said. A number of US personnel were being evaluated for traumatic brain injuries and one Iraqi service member was wounded, it said.

The United States also said it had targeted a missile the Iran-backed Houthi group in Yemen was aiming into the Red Sea, which it called a threat to shipping.

Saudi Arabia’s foreign minister said the kingdom was “very worried” that tensions in the Red Sea amid attacks by Yemen’s Houthis and US strikes on Houthi targets could spiral out of control and escalate the conflict in the region.

“I mean, of course, we are very worried. I mean, you know, we are in a very difficult and dangerous time in the region, and that’s why we are calling for de-escalation,” Prince Faisal bin Farhan told CNN ‘Fareed Zakaria GPS’ in an interview that will be aired on Sunday.

Attacks by the Iran-aligned Houthi militia on ships in and around the Red Sea for the past several weeks have slowed trade between Asia and Europe and alarmed major powers in an escalation of the war in Gaza –Reuters